From Standard of Care
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An endemic treponematosis.
Caused by Treponema pallidum subspecies pertenue.
Affects children and adults in poor rural areas of tropical countries.
Affects mainly skin, bones and cartilage.
Causes disfiguring skin and bone lesions.
Has primary, secondary and tertiary stages.
Unless treated early, can become a chronic relapsing disease.
Can lead to deforming bone lesions.
Penicillin drug of choice to endemic treponematoses.
WHO recommends one injection of long-acting benzathine benzylpenicillin at a dose of 1.2 MU for adults and 0.6 MU for children.
Oral phenoxymethylpenicillin 50mg/kg/d in 4 doses for 7-10 days is effective therapy.
A sinle oral dose of azithromycin 30mg/kg is non-inferior to benzathine benzylpenicillin (Mitja O et al).