From Standard of Care
Autoimmune epithelial inflammation characterized by lymphocytic infiltration of exocrine glands and epithelial cells in multiple sites.
A systemic chronic inflammatory disorder with lymphocyte infiltrates in exocrine organs.
Has many extra glandular features including arthralgias, arthritis, myalgias, gastrointestinal disease, Raynaud’s disease, anemia, leukopenia, lymphadenopathy, neuropathy, vasculitis renal tubular acidosis and lymphoma.
Primary disease occurs in the absence of an underlying rheumatic disease.
Secondary syndrome reflects the presence of an underlying rheumatic disease, such as rheumatoid arthritis, systemic lupus erythematous or scleroderma.
Chronic disorder characterized by dry mouth and dry eyes.
Typically 8-10 years from initiation of symptoms to diagnosis.
Dental complaints are common.
Anti-Ro/SS-A antibodies are detected in 90% and anti-SS-B antibodies are present in 60% of patients with Sjogren's syndrome.
20% have a MALT lymphoma and chronic parotid enlargement.