Ras oncogene
From Standard of Care
Involved in transducing extracellular mitogenic signals.
Refers to rat sarcoma viral homolog.
A constituent of the MAP kinase pathway and mutations are found in approximately 20% of metastatic melanoma.
Mutations common in acute myelogenous leukemia and high grade myelodysplastic syndrome.
Proteins important in signal transduction in molecular oncology.
A member of a large superfamily of low molecular weight guanosine-5’-triphosphate (GTP) binding proteins.
Proteins that help control signaling pathways that regulate cell proliferation, survival and differentiation.
Members of the Ras family are HRAS, KRAS and NRAS.
Somatic mutations in malignancies introduce amino acid substitution at 12, 13, 61 positions.
