Large cell carcinoma of the lung
From Standard of Care
Make up about 5% of lung cancers.
These lesions show no evidence of squamous or glandular differentiation Non-Small Cell Carcinoma of the Lung (NSCLC).
Approximately 50% of lesions express TTF1, but CK 1,5,10,14 and 20 are rarely expressed.
May have histologic features suggestive of neuroendocrine differentiation with neuronal markers.